Phosphatidyl choline을 글루코즈용액에 현탁시켜 multilamellar liposome을 만들었다. Liposome의 bilayer 사이의 반발력과 인력과의 관계를 분광법을 써서, liposome의 생체막과 유사한 현상인 삼투압적 성질로 관찰하였다. Liposome중에 전하를 띄는 물질 (dicetylphosphate, stearylamine)을 첨가하여 그 양을 증가시키자 liposome의 삼투압적 성질이 증가하였다. Liposome이 현탁되어 있는 medium의 이온강도가 증가할수록 liposome의 부피가 감소하였으며 상투압적 성질도 감소하였다.
Multilamellar liposomes were formed spontaneously when isolated phospholipids were dispersed in glucose solution. And the effects of the amount of charged molecules in bilayer of the liposomes and the ionic strength of the medium on the forces between the bilayers of the liposomes were observed through the osmotic behavior of the liposomes using spectrophotometry. The greater the content of charged molecules, the more sensitive the osmotic behavior. The osmotic behavior of the liposomes was decreased according to the increase of the ionic strength of the glucose solution, and there was no volume change under more than 0.1 of ionic strength.
