털목이버섯의 저분자 독성물질로부터 다음과 같은 결론을 얻었다. 털목이버섯 열수추출액의 $LD_{50}$은 복강 및 경구투여시 각각 1.25와 4.18 g/kg이었다. 건조 털목이버섯 100 g에는 650$sim$700 mouse lethal unit(=MLU)이 함유되어 있었다. 열수총추출액, C분흑 및 최종성분의 1 MLU는 각각 및 28.5, 25.0 및 12.0 mg/mouse이었다. 독성물질의 일반적일 증상은 행동둔화, 체모기립, 전율, 두부진동, 안구돌출, 사지마비, 사망직전의 급격한 다리운동 및 호흡마비 등이었다.
To screen biologically active components of the higher fungi of Korea, the dried carpophores of Auricularia polytricha were extracted with water. The extract was examined for acute toxicity in ICR mice. A low molecular weight toxin of this fungus was purified by a acetone precipitation followed by cellulose, silica gel and Sephadex LH-20 column chromatography. Major symptoms of this toxin were decreasing of normal motility, eye extrusion, hair erection, shivering, trembling of head, paralysis, rapid running or moving before death and depression of respiration. The median lethal doses of the total extract were 1. 28 g/kg and 4. 31 g/kg by i.p. and p.o. administrations, respectively. The amounts of one mouse lethal unit of the total extract and final fraction that killed a 20 g mouse within 30 minutes were 28.5 and 12.0 mg/mouse, respectively.
