Although the Insamyangwee-Tang has been widely used in clinical purposes in the oriental medicine and its clinical efficiency is documented for the cases of gastritis, gastric ulcer and enteritis but the experimental study on these has not been undertaken. So,To investigate the clinical efficiency, of Insamyangwee-Tang and validate its oriental medical theory, these experiments were undertaken, by being compared with animal experiment. ?The following results were obtained. ?1. By effect of Insamyangwee-Tang on isolated ileum from mice, rats, rabbits and Guinea pigs, the motility of ileums was inhibited remarkably. ?2. By effect of Insamyangwee-Tang on motility of the small intestine in rabbits, the motility was inhibited remarkably too. ?3. Insamyangwee-Tang inhibited charcoal transport functions in the small intestine of mice. ?4. By effect of Insamyangwee-Tang on isolated duodenum from rats, the motility of duodenum was inhibited remarkably.?5. Gastric juice and pepsin secretion was decreased, anti-ulceration effect was recognized.