Crytococcosis is a subacute or chronic, very rare in incidence and very often fatal infection caused by Cryptococcus Neoformans. The organism is of world-wide distribution, affecting both sexes and all ages. The most common portals of entry appear to be respiratory tract. Recently we experienced one case of isolated Cryptococcal Granuloma on the right lower lobe. The patient was 63 year old housewife, who complained only of epigastric pain. On baseline studies of chest X-ray, we incidentally found the abnormal finding of mass density on right lower lobe.