Antiseptics are substances that kill or prevent the growth of microorganisms when applied to living tissue. They must be effective against microoranisms but must also retain their activity in presence of body fluids without being harmful locally or systemically. Among many antiseptics. $Betadine^{(R)}$ has been widely used because of its low toxicity and high germicidal efficacy. We reported 2 cases of allergic contact dermatitis to $Betadine^{(R)}$ in surgical patients. They had eczematous eruption along the $Betadine^{(R)}$ applying sites. Patch tests with $Betadine^{(R)}$ confirmed the diagnosis.