The effectiveness and side effects intraarterial use of prostaglandin Esub 1 as a vasodilator were evaluated in 40 peripheral arteriographies which were performed on 20 patients at Hnanyang Univ. Hospical from Dec. 1985 to Mar. 1987. Both control and PGEsub 1-used arteriographies were performed on each patient. In PGEsub 1 study, 20$mu$g of prostaglandin Esub 1 was slowly injected for 39 seconds intrarterially 30 seconds before injection of contrast media. The peripheral arteriographies using intraarterial PGEsub 1 were more effective in diagnostic arteriography without any significant hemodynamic side effects. RESULTS : 1. The PGEsub 1used arteriograms revealed more earlier visualization of optimal phase than control arteriograms in most of the patients, as well as in visualization of venous system. 2. There were greater incidence of peripheral visualization of arterial branches and improved opacification of arterial system in PGEsub 1-used arteriograms than in co trol arteriograms. 3. In PGEsub 1study, the total amount and injection speed of contrast media should be increased to obtain better arteriogram. 4. There was no significant hemodynamic side effects after intraarterial use of prostaglandin Esub 1.