The debonding of clad steel was often occurred at interface between stainless steel and carbon steel during the fabrication of pressure vessel. In order to clarify the causes of debonding phenomena, the fabrication sequences were fully analyzed. As a result, possible factors were noticed for causing the debonding of clad steel, that is, thermal treatment on weldment and welding. Moreover the existence of hydrogen diffused from surroundings also expedites the debonding of clad steel. In this stud, the effect of welding thermal cycle, hydrogen and mixed condition under thermal treatment on the interfacial strength of clad steel were investigated to understand the debonding mechanism of clad steel. From this study, it has been confirmed that the interfacial strength of clad steel was remarkablely deteriorated due to welding and/or existence of hydrogen under thermal treatment. In the case of welding thermal cycle effect, the higher temperature at interface experienced by welding, the more reduction in interfacial strength of clad steel resulted in. And the existence of diffusible hydrogen also reduced the interfacial strength. It is also found that the interfacial strength of clad steel became much lower value than that of the as-received plate under coexistence of above mentioned factors.