The effects of ginseng ethanol extract on the toxicity of lead acetate in mice were examined. Mice were given intraperitoneally daily doses of lead acetate 50 mg/kg with ginseng ethanol extract 50 mg/kg, 100 mg and 200 mg/kg for 3 weeks. The exposure of lead acetate showcd the toxicity at all experimental assay such as the gain of body weight, the ratio of some organs weight to body weight, serum transaminase activity and creatinine value, hematocrit and WBC counts. These toxicities were inhibited significantly by the ginseng ethanol extract administration. The 50 mg/kg and 100 mg/kg administration of ginseng ethanol extract inhibited histopathological changes on kidney by lead acetate, whereas the 200 mg/kg administration of the fraction enhanced histopathological changes.