Synthetic $eta$-Lactam Antibiotics II. Synthesis and Antibacterial Activity of 7$eta$-[2-(2-Aminothiazol-4-yl)-2-(methoxyimino)acetamido]-3-[1-(halosubstitutedphenyl)-1H-tetrazol-5-yl]thiomethyl-cephalosporins

Synthetic $eta$-Lactam Antibiotics II. Synthesis and Antibacterial Activity of 7$eta$-[2-(2-Aminothiazol-4-yl)-2-(methoxyimino)acetamido]-3-[1-(halosubstitutedphenyl)-1H-tetrazol-5-yl]thiomethyl-cephalosporins
Synthetic $eta$-Lactam Antibiotics II. Synthesis and Antibacterial Activity of 7$eta$-[2-(2-Aminothiazol-4-yl)-2-(methoxyimino)acetamido]-3-[1-(halosubstitutedphenyl)-1H-tetrazol-5-yl]thiomethyl-cephalosporins

ㆍ 저자명: Koh. Dong-Soo,Kim. Joong-Hyup,Park. Sang-Woo,Kim. You-Seung
ㆍ 간행물명: Bulletin of the Korean Chemical Society
ㆍ 권/호정보: 1987년|8권 5호|pp.418-421 (4 pages)
ㆍ 발행정보: 대한화학회
ㆍ 파일정보: 정기간행물|ENG|
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ㆍ 주제분야: 기타

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기타언어초록

Syntheses of cefotaxime analogs with halosubstituted phenyltetrazolthiomethyl at the $C_{3^-}$position are described. Their in vitro potency was established. The compounds exhibited a broad antibacterial spectrum. Some of these compounds showed activity against Gram-positive bacteria superior to the parent cefotaxime. Against Gram-negative bacteria, these compounds are less effective than cefotaxime.

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