- 수용성 담체와의 공침물 형성에 의한 메토클로프라미드의 용출 증가
- ㆍ 저자명
- 용재익,정차옥,Yong. Jae-Ick,Jeong. Cha-Ok
- ㆍ 간행물명
- 藥劑學會誌
- ㆍ 권/호정보
- 1988년|18권 2호|pp.43-47 (5 pages)
- ㆍ 발행정보
- 한국약제학회
- ㆍ 파일정보
- 정기간행물| PDF텍스트
- ㆍ 주제분야
- 기타
In order to increase the dissolution characteristics of relatively water-insoluble metoclopramide (MCP), coprecipitates of MCP with polyvinylpyrrolidone (PVP), polyethylene glycol (PEG) 1000, 4000 or 6000 were prepared in various drug to polymer ratios. The dissolution rate of MCP-PVP coprecipitate was greater than those of MCP alone, MCP-PVP physical mixture and MCP-PEG coprecipitates. The dissolution rate of MCP-PEG 6000 coprecipitate was greater than those of MCP-PEG 1000 and MCP-PEG 4000 coprecipitates. The dissolution half-lives $(T_{50%})$ for MCP alone and 1:5 (w/w) MCP-PEG 6000 coprecipitate were determined by the log-probit method at $37^{circ}C$ and found to be 4.17 and 0.98 min, respectively.