A radiographic bone survey and radionucilde bone scan are the principal methods for the detection of metastaic bone diseases. A retrospective study of 99m Tc-MDP bone scan in 169 patients with various tumors over a period of 2 years recealed 82 patients having metastasis to skeletal system. The bone scan findings in these 82 cases were correlated with clinical symptoms laboratory data and radiographic studies. The results were as follows : 1. Male to female ratio was 47:35 . The 7th decade (25 cases, 30.5%) was the most prevalent age group followed by the 8th decade (22 cases 26.9%) and the 6th decade (21 cases 25.6%) 2. The primary sites of metastases were lung (36 cases 43.9%) followed by stomach and prostate (9 cases each 43.9%) breast (8 cases 9.7%) liver (4 cases 4.7%) Kidney and lymphoma (3 cases 3.7%) 3. False negative radiographic bone survey was seen in 47 cases (57.3%) of 82. 4. 52 cases(63.4%) showed elevated serum alkaline phoshatase and it was significant especially in patients with bone pain alog with the elevation of serum calcium and phosphorus. 6. The metastatic sites in skeletal system were ribs and sternum(35 cases) lumber spine(32 cases) thoracic spine (25 cases) lower extremity (19 cases pelvis (18 cases), upper extremity (6 cases) and skull and face (2 cases).