Cenerally non-ionic water-soluble contrast media has been known to be considerably better than the con-ventional ionic contrast agents because of its physiochemical properties which are more hydrophilic lower in osmolality than the ionic agents of equivalent iodine concentration. It means that the non-ionic agent has less side reactionand better general tolerance. lopromide (Ultravist) is a newly developed non-ionic contrast media that is suitable for angiography. Some non-ionic contrast media such as Metrizamide and lopamidol were clinically introduced and proved tobe the most compromising agents for neuroradiographic study but lopromide is not yet freely avalilable in the vascular study. In order to evaluate the clinical fitness and its side effects of lopromide for angiography various type of angiography were done in 136 patients using lopromide and ionic contrast media Diatrizoate meglumine for comparison 85 patients received lopromide and 51 received Diatrizoate moglumine (DTM). Similar volumes of the contrast media was administered at similar rate to both groups. The results were as the follows: 1. In celiac angiography of 31 patients with lopromide (Ultravist 370) and 18 with DTM 60there were observ-ed 9.7% mild pain and 25.8% mild heat sensation in lopromide. In DTM 60 mild pain was approximately 3 times more frequently observed than lopromide. Heat sensation is mild and similar in frequency of both groups. There was no clinically significant side effects resated to the osmolality and its difference between two groups. 2. In peripheral angiography of 47 patients with lopromide 300 and 24 with DTM 60 there were observed 19.1% mild 6.4 moderate in pain and 46.8% mild 1% moderate heat sensation in lopromide. But in DTM there were 33.3% mild 58.3% moderate and 8.3% severe pain and also 70.8% mild and 16.7% moderate heat sensation in DTM were observed. lopromide is more advantageous and better contrast agents than the DTM for peripheral vascular study on the point of low side effect related to osmolality. 3. In renal angiography there was no clinically significant side effects and its difference between two groups. 4. among 85 patients with lopromide and 51 with DTM there were 8% general side effects in lopromide and 17.6% In DTM in iopromide and 51 with DTM there were 8% general side effects in lopromide and 17.6% in DTM in lopromide they were nausia (7.1%) chilling (1.2%) and Hypotension (1.2%) The frequency of general side reactionwas not significantly different between two groups. 5. The quality of angiogram with lopromide and DTM was "good" in almost cases and there were no clinically diffrence between two groups.wo groups.