Gastrointestinal bleeding remains a major diagnostic problem. Although advances have been made in the medical and surgical methods of managing gastrointestinal bleeding the commonly employed techniques of barium radiography endoscopy and angiography may not successfuly localize the site and define the cause of gastrointestinal bleeding. Two widely available technetium-99m-labeled radiophamaceuticals sulfur colloid and red blood cells are currently used in the evaluation of patients who are bleeding from the gastrointestinal tract. surgically confirmed 19 patients with use of 99m Tc-sulfur colloid (7cases) and 99m Tc-RBC(12cases) were retrospectively evaluated, The overall sensiticity of scintigraphy in detection of bleeding and localization of bleeding site was 68% and 84% respectively. the authors conclude that bleeding scintigraphy is a safe sensitive and non-invasive method as an effec-tive screening test before performing angiography or surfery, .