Castleman`s disease is a rare disease entity of unknown etiology, with the characteristics of large, well marginated benign lymph node hyperplastic mass. This disease occurs predominantly in the mediastinum but also occurred in other areas of the body usually where lymph nodes are normally found. They have been divided into two histologic types: the hyaline vascular lesion which comprises over 90% of the cases; the plasma cell lesions, which was characterized by large follicle with plasma cell and systemic manifestation, such as fever, anemia elevated ESR, hypergammaglobulinemia, hypoalbuminemia. This disease have behaved in a benign fashion and complete surgical excision is the choice of treatment. We experienced a case of Castleman`s disease which was treated by surgical resection through the thoracotomy, and has good postoperative and follow up result. We report a case of the Castleman`s disease with its review.