The effects of ginsenosides on the development of morphine induced tolerance and physical dependence were investigated. $Rb_1,;Rb_2,;Rg_1;and;Re$ inhibited significantly the development of morphine induced tolerance but $Rb_1;and;Rg_1$ showed significant inhibitory effect on the naloxone induced withdrawal jumping response. Ginsenosides inhibited the body weight decrease in physically dependent mice during multiple injection of morphine.