A series of malignant small cell tumors primarily involve the soft tissue of the chest wall and lung was described by Askin in 1970 This rare a neuroepithelial origin and affects children and young adult charcteristically. Histologic overlap between other small cell neo-plasms usually makes differentiation difficult and immunochemical and electron microscopic features play a role in differentiation. Radiologic appearence was chest wall or pleural based mass with or without rib destruction and /or pleural change. Authors experienced two cases of malignant small cell tumor of the thoracopulmonary region and report with review of literatures.