The hydrodenitrogenation of quinoline dissolved in n-heptane was studied over sulfided Ni-Mo/$gamma-Al_2O_3$ catalyst at the range of the temperature between 553 K and 673 and the total pressure between $20 imes 10^5$ Pa and $60 imes 10^5$ Pa in a fixed bed flow reactor. Quinoline conversion was very high at relatively low temperature and total pressure, and decreased with quinoline partial pressure. The thermodynamic equilibrium between quinoline and Py-THQ existed in wide ranges of experimental conditions and shifted in favor of quinoline at higher temperature. At the range of the temperature betwwen 553 K and 673 K and at the total pressure $60 imes 10^5$ Pa, the quinoline reaction rate was 1st order with respect to the concentr4ation of quinoline and its apparent activation energy was 7.15 Kcal/mole.