In this paper, 16-QAM and 49-QPR systems utilized the raised cosine filter instead of LPF with the rectangular frequency characteristics as limiting channel bandwidth are implemented to measure their performances and effects of ISI. With the use of the raised cosine filter, and increase in SNR immunity can be obtained for specified spectrally efficient applications. Examination of the measured results reveals that the bandwidthe efficiency of 49-QPR implement is improved by about 8% and 15% higher than those of 16-QAM implement with the raised cosine characteristics having roll-off factor, a=0.5 and a=1, respectively. Also, equations for eye diagrams and error probability of 49-QPR system with AWGN and ISI are derived to analyze its performance and compared with the case of 16-QAM system.