This study investigated the effect of changing position from supine to standing upright on the circulation of young men and women. Healthy men and women ranging from age of 18 to 24 were examined. Two minutes before standing, the baseline heart rate and blood pressure were measured. Heart rate and blood pressure were recorded immediately and at every minute for 10 minutes after standing upright. Differences in heart rate and blood pressure between supine and standing upright position were evaluated. The results were summarized as follows : 1. Heart rate increased significantly immediately and at every minute for 10 minutes after standing upright. 2. Systolic blood pressure increased significantly immediately and at every minute for 4 minutes after standing upright. 3. Diastolic and mean blood pressure increased significantly immediately and at every minute for 10 minutes after standing upright. 4. Pulse pressure immediately and at every minute for 10 minutes after standing upright was significantly narrower than that of supine position. 5. There was no significant difference of heart rate between men and women after standing upright. 6. Systolic and diastolic blood pressure of men after standing upright was significantly greater than those of women. From these results, it may be concluded that heart rate, systolic, diastolic and mean blood pressure and pulse pressure increase after standing upright, and systolic and diastolic blood pressure in men is greater than those of women after standing upright.