Thirteen patients with various musculoskeletal inflammatory conditions and 2 postherpetic neuralgia patients received transcutaneous iontophoresis with dexamethasone sodium phosphate (1 ml = 4 mg) and 4% lidocaine hydrochloride (2 ml=80 mg, direct current 4 mA, 20 min.). Seven patients showed excellent pain relief, 4 patients showed good pain relief, and the rest of the patients had fair or poor pain relief. No side effects were seen but skin irritation and painless electrical bum were common. Results of the study indicate that iontophoresis is an effective treatment of inflammed tissues which guarantees a painless, safe and sterile method.