- Bufexamac의 합성
- Synthesis of Bufexamac
- ㆍ 저자명
- 최홍대,마정주,Choi. Hong-Dae,Ma. Jung-Jeo
- ㆍ 간행물명
- 약학회지
- ㆍ 권/호정보
- 1990년|34권 3호|pp.212-214 (3 pages)
- ㆍ 발행정보
- 대한약학회
- ㆍ 파일정보
- 정기간행물| PDF텍스트
- ㆍ 주제분야
- 기타
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A new synthetic method for bufexamac, which is a potent anti-inflammatory agent, was described. Friedel-Crafts reaction of butoxybenzene (2) with ethyl ${alpha}-chloro-{alpha}-(methylthio)acetate$ (1) gave ethyl 2-methylthio-2-(p-butoxyphenyl) acetate (3). Ethyl 2-(p-butoxyphenyl)acetate (4) was prepared by desulfurization of compound (3) with zinc dust-acetic acid. Bufexamac (5) could be easily synthesized by treatment of compound (4) with hydroxylamine HCl.