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A Model for Diffusion and Dissolution Controlled Drug Release from Dispersed Polymeric Matrix
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  • A Model for Diffusion and Dissolution Controlled Drug Release from Dispersed Polymeric Matrix
  • A Model for Diffusion and Dissolution Controlled Drug Release from Dispersed Polymeric Matrix
저자명
변영호,최영권,정서영,김영하,Byun. Young-Rho,Choi. Young-Kweon,Jeong. Seo-Young,Kim. Young-Ha
간행물명
藥劑學會誌
권/호정보
1990년|20권 2호|pp.79-88 (10 pages)
발행정보
한국약제학회
파일정보
정기간행물|ENG|
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기타
이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
서지반출

기타언어초록

A numerical model for diffusion and dissolution controlled transport from dispersed matrix is presented. The rate controlling process for transport is considered to be diffusion of drug through a concentration gradient coupled with time-dependent surface change and/or disappearance of the dispersed drug in response to the dissolution. The transport behavior of drug was explained in terms of ${ u}$ parameter: ${ u}$ value means a ratio of diffusion time constant and dissolution time constant. This general model has wide range of application from where release is controlled by the diffusion rate to where release is governed by the dissolution rate. Based on this model, theoretical drug concentration, particle size distributions in the polymer matrix system and the resulting release rate were also investigated.