The following results were obtained from the observation on the change of plasma cortisol concentration and arterial blood $PO_2,;PCO_2$ in the experiment of intravenous and oral administration of Chung Sang Bo Ha Tang Water Extract in the rabbit. 1. In intravenous administration, the plasma cortisol conce-ntration increased significantly about 2 hours after with a dose of $0.2m{ell}/kg$, while the case of $0.4m{ell}/kg$ reveals this significant increase of concentration about 3 hours after. 2. In oral administration, a significant increase of the plasma cortisol concentration was shown about 2 and 4 hours after with a dose of $1.2m{ell}/kg$, on the other hand, an increase of concentration was shown at each hour in the case of $0.2m{ell}/kg$, but it was not significant. 3. In oral administration, $PO_2$ in arterial blood increased significantly in the case of $0.2m{ell}/kg$, and both the case of $0.1m{ell}/kg$ and that of $0.2m{ell}/kg$ gave a significant decrease of $PCO_2$ in arterial blood. With these results, it is verified that Chung Sang Bo Ha Tang has therapeutic effects on JISU(止嗽), JEONG CHEON(定喘), GEO DAM(祛痰) because intravenous and oral administration of it increases the plasma cortisol concentration, However, in the examination of $PO_2$ and $PCO_2$ in arterial blood, any remarkable result was not obtained.