To evaluate effects of Ga Gam Sam Kee Tang(GGSKT) water extract on the plasma cortisol concentration and arterial blood $PCO_2,;PO_2$ in the rabbit. The results obtained were as follows : 1. Intravenous administration of GGSKT water at the dose of $0.2m{ell}/kg$ remarkably increased plasma cortisol concentration from 1 to 2 hours. 2. Oral administration of GGSKT water extract at the dose of $10m{ell}/kg$ significantly decreased plasma cortisol concentration on 3 hours. 3. Intravenous administration of GGSKT water extract at the dose of $0.4m{ell}/kg$ remarkably decreased arterial blood $PO_2$ on 2 hours. 4. Oral administration of GGSKT water extract at the dose of $1.0m{ell}/kg$ significantly decreased arterial blood $PO_ 2$ on 2 hours and remarkably increased on 4 hours. 5. Intravenous administration of GGSKT water extract at the dose of $0.2m{ell}/kg$ remarkably increased arterial blood $PCO_2$ on 4 hours. 6. Oral administration of GGSKT water extract at the dose of $2.0m{ell}/kg$ significantly decreased arterial blood $PCO_2$ from 1 to 2 hours. These results suggest that therapeutic action of GGSKT water extract for athma may be related with the increment of plasma cortisol concentration and the decrease of arterial blood $PCO_2$