This problem in this paper concerns the determination of safety stock for multi-echelon invenetory system. In this model the criterion is to minimize system safety stock subject to a service level constraint and expected annual total cost. Then, safety stock is determined by minimizing expected annual total cost and satisfying given service level. This expected annual total cost is obtained by expected total inventory holding cost plus the expected total stockout cost. Numerical example is given in a three-echelon inventory system. The results obtained by the use of the Hill Algorithm.