The hepatic artery chemoembolization with Lipiodol, doxorubicin, Gelfoam was performed in 14 mongrel dogs to evaluate embolic effect of these materials to normal liver parenchyma. Fourteen dogs were divided into four experimental groups according to the kinds of embolic materials, 3 dogs with 0.1ml/kg of Lipiodol(Group 1), 4 dogs with 0.1ml/kg of Lipiodol and 0.5mg/kg of doxorubicin(Gruop 2), 4 dogs with Lipidol, doxorubicin and 150-300 pieces of 0.5x0.5cm sized Gelfoam(Group 3), 3 days, 1 week, 2 weeks and 3 weeks after embolization. Pathologic examination was performed 3 weeks after embolization. Lipiodol densities in group 1 were cleared 2 weeks after embolization, and in group 2, patch and nodular Lipiodol densities were changed to mottled and streaky densities 3 weeks after chemoembolization. In group 3, patch and nodular Lipiodol densities were still remained 3 weeks after chemoembolization. Histopathologic examination showed nonspecific pathologic changes such as fatty change of hepatocyte or intravascular congestion in group 1 and 2. However, in group 3 and 4, there were significant pathologic damages of the liver such as hepatocellular necrosis and interstitial hemorrhage. In conclusion, Lipiodol-CT for the diagnosis of hepatic tumors is recommended to be performed 2 weeks after Lipiodol infusion, and in case of chemoembolization with Lipiodol and Gelfoam, superselection of supplying vessels of tumors is necessary to avoid the possible parenchymal damage of the normal liver.