This BEF will be resolved with tissue adhesive application The bronchoesophageal fistula[BEF] is a rare lesion in thoracic surgical diseases & is difficult to be closed surgically. Tissue adhesives has been used widely in surgical fields, or in endoscopy, for some time and seems to be potentially useful in cardiothoracic surgery. We have experienced the closure of BEF with tissue adhesive Tisseel in 2 cases recently. One is 60 years old male who had taken the closure of BEF with Tisseel through right bronchotomy. The other is 57 years old female who had taken the closure of BEF with Tisseel with flexible gastrofiberscopy. The postoperative courses are uneventful for 4 months to now.