Lead acetate solution were intraperitoneally injected to rats of average body weight 220g to cause lead poisoning. Antidotes were orally administered using catheter to the rats and the urine was collected after 24 hours. ALA in the urine were determined by U. V. spectrophotometer. Antidotes used in this experiment were the water extracts of scutellaria radix and D-penicillamine solution. ALA in the urine was determind by Wada method. It was found that ALA content in the urine was decreased after oral administration of water extracts of scutellaria radix and D-penicillamine solution. In this study it is believed that water extract of suctellaria radix could be used as an excellent antidate in lead poisoning.