The crystal structure of eprazinone dihydrochloride, $C_{24}H_{32}N_2O_2$${cdot}$2HCl, has been determined from 2102 independent reflections collected on an automated Nonious CAD-4 diffractometer using graphite-monochromated $Mo-Kalpha$ radiation. The crystals are monoclinic, space group P$2_1$/n, with unit cell dimensions a=11.381(2), b=28.318(2), c=7.840(1) $AA$, $eta=92.45(2)^{circ}$, ${mu}=2.37$ c$m^{-1}$, F(000)=968, and Z=4. Final R value is 0.071 for independent 2102 observed reflections. The molecule assumes an extended conformation. The piperazine ring has a normal chair conformation and the four carbon atom are planar with a maximum displacement of 0.004 $AA$ for C(18) atom. The two chloride ions are hydrogen bonded to the two piperazine nitrogen atoms [N(14)${cdot}{cdot}{cdot}$Cl(1); 2.986(6) $AA$ N(17)…Cl(2); 3.084(8) $AA$].