Effects of insulation after exposure of the extremities on the temperature regulation in clothed men were studied. Experiment was carried out with six males in a climatic chamber fixed at $10^{circ}C$, $55\%$ R.H. treated with Type A (face only was exposed) and Type B (face and half of the extremities were exposed). Mean skin temperature fell greater in Type B due to intense vasoconstriction than in Type A. Rectal temperature rose a little in Type B and resumed in Type A without any significant differences in metabolism between two types of clothing. These findings suggest that Type B is more effective in physiological defense to the cold stimuli than Type A at least at $10^{circ}C$.