The Pulmonary Infiltration and Eosinophilia Syndrome (PIE Syndrome) includes a wide spectrum of clinical disorders with pulmonary infiltrates and peripheral eosiophilia. It is poorly understood and ill-defined group of disorders. Often its etiology is poorly delineated. There may exist an eosinophilic type of alveolitis in the category of PIE syndrome. It shows characteristic clinical picture, peripheral eosinophilia and especially dramatic improvement following therapy with corticosteroids. We report a case of the syndrome in 43-year-old man with brief review of contemporary literature. In this case, the diagnosis was confirmed by open lung biopy which showed characteristic eosinophilic alveolitis accompanied by periphiral eosinophilia. Corticosteroid was administered with rapid clinical improvement in this case.