항대사물질 6-aminonicotinamide가 메추리 조직내 조효소 및 효소에 미치는 영향을 조사하였다. 6-aminonicotinamide를 동물체중의 kg당 15mg 투여했을 때 흉부근육조직의 NAD와 ATP 함량은 현저히 감소하였으나 NADP와 NADPH의 함량은 변화하지 않았다. 흉부근육조직의 glyceraldehyde-3-phosphate dehydrogenase 활성은 현저히 감소하였으나 lactic dehydrogenase와 aldolase 활성은 변화하지 않았다. 간 조직의 경우 NAD, NADP, NADPH 및 ATP 함량은 변화하지 않았다. Malic enzyme 활성은 저하되었으나 glyceraldehyde-3-phosphate dehydrogenase와 fructose bisphosphatase 활성은 영향을 받지 않았다.
The effects of antimetabolite, 6-aminonicotinamide(6-AN) on levels of nicotinamide coenzymes and enzymes in quail tissues were investigated. The intraperitoneal administration of 6-AN (multiple doses of 15 mg/kg body weight) gave rise to a marked reduction in NAD and ATP levels in pectoral muscle but did not exert any influence on NADP and NADPH levels. A pectoral muscle glyceraldehyde-3-phosphate dehydrogenase activity was significantly reduced but lactic dehydrogenase and aldolase activities were not affected. In liver NAD, NADP, NADPH, and ATP levels were not affected to any extent by 6-AN. Similarly, activities of liver glyceraldehyde-3-phosphate dehydrogenase and fructose bisphosphatase were not affected by 6-AN but malic enzyme activity was significantly lowered.
