$7{eta}$-(5-Aryl-2H-tetrazol-2-yl)acetamidocephalosporanic acid($23{sim}26$) and $7{eta}$-(5-Aryl-4-phenyl-4H-1, 2, 4-triazol-3-yl)thioacetamidocephalosporanic acid were synthesized by condensation of 5-Aryl-2H-tetrazol-2-acetyl chloride($17{sim}20$) and 5-Aryl-4-phenyl-4H-1, 2, 4-triazol-3-thioacetyl chloride($22{sim}24$) with 7-Aminocephalosporanic acid(7-ACA), respectively. These seven compounds were tested in vitro antimicrobial activity. These exhibited good antimicrobial activity against Gram-positive bacteria whereas most compounds showed decreased antimicrobial activity against Gram-negative bacteria
$7{eta}$-[5-(2-Methoxy)benzyl-2H-tetrazol-2-yl]acetamidocephalosporanic acid$7{eta}$-[5-(15-Dimethyl-2-Pyrrole)-2H-tetrazol-2-yl]acetamidocephalosporanic acid$7{eta}$-[5-(345-Trimethoxyphenyl)-2H -tetrazol-2-yl] acetamidocephalosporanic acid$7{eta}$-(5-N aphthyl-2H-tetrazol-2-yl] acetamidocephalosporanic acid$7{eta}$-[5(4-Methylphenyl)-4-phenyl-124-triazol-3-yl]thioacetamidocephalosporanic acid[5-(24-Dichlorophenyl)-4-phenyl-4H-124-triazol-3-yl]thioacetamidocephalosporanic acid$7{
