- 4-비페닐아세트산(펠비낙)의 합성
- ㆍ 저자명
- 최홍대,윤호상,강병원,Choi. Hong-Dae,Yun. Ho-Sang,Kang. Byung-Won
- ㆍ 간행물명
- 약학회지
- ㆍ 권/호정보
- 1992년|36권 2호|pp.126-128 (3 pages)
- ㆍ 발행정보
- 대한약학회
- ㆍ 파일정보
- 정기간행물| PDF텍스트
- ㆍ 주제분야
- 기타
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A new method for felbinac, which is a potent anti-inflammatory agent, is described. Friedel-Crafts reaction of biphenyl with ethyl ${alpha}-chloro-{alpha}-(methylthio)acetate(1)$ afforded ethyl 2-methylthio-2-(4-biphenylyl)acetate(4). Felbinac (7) was synthesized by desulfurization of compound (4) with zinc dust in acetic acid, followed by hydrolysis of the resultant ethyl 2-(4-biphenylyl)acetate (6).