Preparation and Characterization of Poly$({gamma}-benzyl;L-glutamate)$/Poly(ethylene oxide)-Lactoselactone Block Copolymers and Their Microspheres

Preparation and Characterization of Poly$({gamma}-benzyl;L-glutamate)$/Poly(ethylene oxide)-Lactoselactone Block Copolymers and Their Microspheres
Preparation and Characterization of Poly$({gamma}-benzyl;L-glutamate)$/Poly(ethylene oxide)-Lactoselactone Block Copolymers and Their Microspheres

ㆍ 저자명: 김영훈,조종수,성용길,정병호,이강춘,Kim. Young-Hoon,Cho. Chong-Su,Sung. Young-Kiel,Chung. Byung-Ho,Lee. Kang-Choon
ㆍ 간행물명: 藥劑學會誌
ㆍ 권/호정보: 1992년|22권 3호|pp.237-240 (4 pages)
ㆍ 발행정보: 한국약제학회
ㆍ 파일정보: 정기간행물|ENG|
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ㆍ 주제분야: 기타

이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.

서지반출

기타언어초록

A series of biodegradable block copolymers consisting of $poly({gamma}-benzyl;L-glutamate)$ (PBLG) and poly(ethylene oxide) (PEO)-lactoselactone were prepared by polymerization of PEO-lactoselactone and ${gamma}-benzyl$ L-glutamate-N-carboxyanhydride and characterized by IR and NMR. From circular dichroism measurements, it was found that the polymers exist in the ${alpha}-helical$ conformation. Block copolymer microspheres were prepared by solvent-extraction-precipitation method for their primary evaluation for medical and biological applications.

키워드

PBLG-PEO-lactoselactone Microspheres Polypeptide Poly(ethylene oxide)

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