This study describes the response performances of actual engine speed, turbocharger speed, air mass flow rate through engine, boost pressure ratio, exhaust temperature and combustion efficiency for a six-cylinder four-stroke turbocharged diesel engine during the change in operating conditions by using the computer simulation with test bed. In order to obtain the transient conditions, a suddenly large load was applied to the simulation engine with the several kinds of inertia moment in turbocharger and engine, and engine set speed. From the results of this study, the following conclusions were summarized The inferior response performances was mainly caused by turbocharger lag, and air mass flow rate and boost pressure ratio were closely related to the turbocharger speed. A reduced moment of turbocharger inertia resulted in less transient speed drop and much faster recovery to the steady state of the engine. The increase of moment of engine inertia reduced cyclic variation of engine speed. When a large load was applied to the engine at high speed, the engine could be fastly recovered. However, when the same load was applied to the engine at low speed, the engine was stalled.