In the previous study, car interior noise was analyzed using structural acoustic mode coupling coefficients and noise response in vehicle compartment model was simulated by the developed special purpose program. As a continued study, this paper presents a practical scheme for the interior noise reduction of a passenger car. Noisy panels on the vehicle compartment wall could be easily identified by the analysis using mode coupling coefficients. Numerical simulation for noise reduction was carried out on a simplified vehicle compartment model by using panel contribution factor and the noise reduction effect was verified by the structural modification test using Steel Skin (damping sheet).