Hydrodesulfurization of thiophene was studied over $Ni-W/TiO_2-ZrO_2$ catalysts in a fixed bed flow reactor. The ranges of experimental conditions were at the temperatures between 200$^circ$C and 360$^circ$C, the pressures between 20 X $10^5$ Pa. The catalysts were reduced with the flow of 10 L/hr of $H_2$ at the temperature of 350$^circ$C. It was found that $TiO_2-ZrO_2$ supported catalysts had similar activity to $gamma-Al_2O_3$ supported. The largest surface areas and the highest acidity occured as the binary oxides were mixed with equal molar ratios. The HDS increased with increasing temperatures, pressures and contact times.