The experimental studies were carried out on ultrafiltration of PEG #6000 and dextran 70T macromole¬cules. using an asymmetric cellulose acetate membrane in a cross flow plane type cell. Effects of pressure difference. feed concentration were studied on permeate flux and observed rejection for both the macromole¬cules. and the concentration polarization layer resistance $R_{b1}$ on permeate flux was analysed. The concentration polarization layer resistance $R_{b1}$ was correlated with the average macromolecule concen¬tration $C_{b1}$ in polarization layer. The resulting dimensionless correlation was expressed as : $frac{R_{b1}}{{R_m}}=alpha[frac{ ho_{b1}}{C_{b1}}]^eta$