Clams were collected from mouth part of Mangeong Gang(river) of which heavy metals were heavily contaminated. Scapharca subcrenata, one of the clams, were fed to mice for 1-2 months with regular food stuffs. Eventhough difference of body weight was recognized between the experimental group and normal diat group, accumulation of heavy metals examined, cadmium was found 1.16 $mu extrm{g}$/gm in liver, 3.31 $mu extrm{g}$/gm in kidney and 0.21 $mu extrm{g}$/gm in blood of experimental group at 60th day, whereas 0.14 $mu extrm{g}$/gm, 0.35$mu extrm{g}$/gm and 0$mu extrm{g}$/gm respectively in normal diet group ate tje same period. No specific histo pathological finding was found in brain and kidney, although slighr fatty change and focal necrosis were found in liver tissues of the experimental group in second month.