This paper offers the simplification method of Multiple-Valued logic function based on M-AND,M-OR, NOT operation presented by Lukasiewicz. First in performing the simplification the result is different by the method to arrange Cube, the method to find the most effective adjacent term if, most of all, important in simplification. According to this method, the two-variable multiple-valued logic function given by truth table is decomposed. The simplification method in this paper proves that the number of devices and cost is considerably reduced comparing with the existing method 141 to realize the same logic functions.