Background: Drug eruptions are one of the most frequently observed adverse reaction to drugs. Method: We analysed clinical types and laboratory findings of in-patients during a 5-year $period(1986{sim}1990)$ who were diagnosed as drug eruption at the department of dermatology. Seoul National University Hospital. These findings were compared with the results of previous 10-year period. Results : Fifty-four patients(10.8/year) were diagnosed as drug eruption. The number of patients was not markedly changed compared with 12.7 patients per a year during previous 10-year period. but the proportion of drug eruption compared with total in-patient of the department of dermatology was diminished from 8.89% to 4.67%. The cutaneous manifestations of drug eruptions in the order of frequency were as follows: exanthematous eruption. Stevens-Johnson syndrome, urticaria, toxic epidermal necrolysis, erythema multiforme, fixed drug eruption, photosensitivity, lichenoid drug eruption. The frequent causative agents of drug eruptions were diphenylhydantoin, ampicillin, acetylsalicylic acid. carbamazepine. Abnormal liver function tests(32.7%), leukocytosis(26.5%) and hypereosinophilia(16.3%) were commonly associated with drug eruptions. Conclusion: The result of this study showed various clinical types and many causative agents of the drug eruption. The main groups of causative agents have remained same but the sulphonamide were decreased in recent years.