- 약물의 서방출을 위한 ${kappa}-Carrageenan$의 응용
- ㆍ 저자명
- 이승진,Lee. Seung-Jin
- ㆍ 간행물명
- 藥劑學會誌
- ㆍ 권/호정보
- 1993년|23권 4호|pp.213-216 (4 pages)
- ㆍ 발행정보
- 한국약제학회
- ㆍ 파일정보
- 정기간행물| PDF텍스트
- ㆍ 주제분야
- 기타
${kappa}-Carrageenan$, an anionic polysaccharide, was employed in tablet formulations and its function as a drug release sustaining agent was investigated. Tablets composed of ${kappa}-carrageenan$ and hydroxypropyl methylcellulose were fabricated by using direct compression method. Lactose and sodium alginate were utilized as controls for ${kappa}-carrageenan$. Drug release experiments performed at pHs 1.2 and 7.4 revealed that ${kappa}-carrageenan$ retains pH-dependent sustained release effects due to its anionic characteristics. Also, the ionic interaction between ${kappa}-carrageenan$ and drugs exerted significant affects on drug release kinetics. ${kappa}-Carrageenan$ was found out to be a useful additive for sustained release tablet formulations.