In order to observe clinical effects of Kwi-Bi-Tang(歸脾湯) and Sa-Mul-An-Shin-Tang(四物安神湯), I reached following conclusion through the physiochemical investigation the following results obtained. 1)In serum Lipid, only Total cholesterol is significantly decresed in medication group of Kwi-Bi-Tang(歸脾湯), but is not in the medicaton of Sa-Mul-An-Tang(四物安神湯). 2). The value of Cardiac enzyme is remarkably decreased in the medication group of Kwi-Bi-Tang(歸脾湯), Only AST is significantly decresed in the medication group of Sa-Mul-An-Tang(四物安神湯). 3) In determination of LDH isoenzyme, LDI is significantly decrease both in the medication group of Kwi-Bi-Tang(歸脾湯) and Sa-Mul-An-Shin-Tang(四物安神湯). Especially, LDI is remarkably decreased in the medication group of Kwi-Bi-Tang(歸脾湯). In view of the results so far achieved, we knew that Kwi-Bi-Tnag(歸脾湯) and Sa-Mul-An-Shin_Tang(四物安神湯) had improved ischemic condition of cardiac muscle, specially, Kwi-Bi-Tnag(歸脾湯) was significant compared to Sa-Mul-An-Shin-Tang(四物安神湯).