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비소세포성폐암에서 방사선치료단독요법과 항암제 병합요법과의 치료결과 비교
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  • 비소세포성폐암에서 방사선치료단독요법과 항암제 병합요법과의 치료결과 비교
  • Therapeutic Results of Radiation Therapy Alone and Combination with Chemotherapy in Non-Small Cell Lung Carcinoma
저자명
김주리,서현숙,Kim. Ju-Ree,Suh. Hyun-Suk
간행물명
대한치료방사선과학회지
권/호정보
1993년|11권 2호|pp.303-309 (7 pages)
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대한방사선종양학회
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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Between November 1983 and December 1992, 121 patients with non-small cell lung cancer were treated with radiotherapy alone or combined with chemotherapy in Inje University, Seoul Paik Hospital. Of these,97 patients were evaluable and analyzed retrospectively. Group 1 (n=62)was treated with radiotherapy alone and group 2 (n=35) combined with chemotherapy. There were 7 patients, 1 patient with stage I and II ,20 patients, 11 patients with stage IIIA,28 patients, 20 patients with stage IIIB, and 6 patients, 3 patients with stage IV, respectively. Ninety percent of patients received more than 5000 cGy of radiaton. Median survival of patients in group 1 was 9 months, group 2 was 15 months. Overall 2 year survival rates of group 1 and 2 were $37\%;and;27\%$, respectively. Relapse free survival rates at 2 year were $27\%;and;15\%$, respectively. Overall survival rates at 5 year for group 1 and 2 were $15\%;and;11\%$, and relapse free survival rates were $16\%;and;6\%,$ respectively. Median survival of complete and partial responders was 47 months in group 1,18 months in group 2, and those of stable or progression was 6 months,11 months, respectively. The proportion of locoregional relapse and distant metastasis was not significantly different between group 1 and 2. The majority of relapse developed within 2 years. Although 2 cases of severe esophagitis and myelosuppression were noted in group 2, the treatment related toxicity was relatively acceptable. Our analysis showed no statistically significant differences between the two treatment groups in terms of response rate, survival, and sites of relapse.