The antipyretic effect of Sibsin-Tang in rabbits by injected typhoid vaccine was studied. The results are summarized as follows; 1. Maximum temperature was $39.76pm0.28^{circ}C$ after 60-240 minutes by injected typhoid vaccine. 2. Sibsin-Tang did not make normal temperature low but aminopyrine made normal temperature low in rabbits. 3. Increased temperature by typhoid vaccine was decreased by administration of Sibsin-Tang at 150 minutes. 4. Pretreated Sibsin-Tang did not affect on increased temperature by typhoid vaccine. 5. Propranolol did not affect on increased temperature by typhoid vaccine.