This paper investigates the problem of a crack approaching two circular holes in an orthotropic infinite plate. The stress intensity factors were obtained by using the modified mapping-collocation method. The present results show excellent agreement with existing solutions for a crack approaching two circular holes in an isotropic infinite plate. In the numerical examples, various types of cross-ply laminated composites were considered. To investigate the effect of orthotropy and geometry(d/R and a/(d-R)) on crack tip singularity, stress intensity factors were considered as functions of the normalized crack length. It is expected that the modified mapping-collocation method can be applied to the analysis of various kinds of cracks existing around the stress-concentration region of composite laminate.