Authors presented the serial changes of brain MRI findings in two cases of cryptococal meningitis. The MRI findings of the first patient (53-year-old female) consisted of dilated virchow-Robin spaces, leptomeningeal enhancement, cryptococcomas and hydrocephalus. Dilated Virchow-Robin spaces were noted on the first MR obtained 33 days after symptom onset. The size and number of dilated Virchow-Robin space gradually decreased since 119 days after sympotm onset (62 days after treatment). Faint leptomeningeal enhancement was found at cerebellar region on the first MRI, which became more distinct and intense on the day 119 probably due to improper treatment. The leptomeningeal enhancement decreased on the day 156. Mild hydrocephalus was noted on MRI obtained 70days after symptom onset, which markedly aggravated on the day 119. It decreased after steroid therapy alone. Enhancing cryptococcomas of variable size were noted at the right temporal lobe and cerebellum on MRI of the day 119 which decreased in size and number on the day 156. On the day 295 MRI showed nearly disappearance of the dilated Virchow-Robin space, but faint leptomeningeal enhancement, cerebellar crptococcomas and hyddrocephalus still remained. The MRI findings of the second patient (36-year-old female) showed the fidings similiar to those of the first patient, Initial MRI obtained 18 days after symptom onset showed no abnormal findings. Dilated Virchow-Robin Spaces were noted on the day 36 (13 days after treatment onset), which nearly disappeared on the day 109. Enhancing cryptococcomas in both basal ganglia and cerebral cortex and leptomeningeal enhancement were noted on MRI of the day 136. Both cryptococcomas and leptomeningeal enhancement decreased in size and enhancing degree on the day 157. Hydrocephalus was noted on the day 109.