6$eta$-(trans-3-Aryl-5-oxo-pyrrolidin-2-yl)acetamidopenicillanic acid(7a~7c) and 7$eta$-(trans-3-Aryl-5-oxo-pyrrolidin-2-yl) acetamidocephalosporanic acid(8a~8c) were synthesized and tested in vitro antibacterial activity. Of these new penicillins exhibited good antibacterial activity against Gram-positive bacteria whereas none of the compounds possessed the activity against Gram-negative bacteria at the concentration tested.
6$eta$-(trans-3-phenyl-5-oxo-pyrrolidin-2-yl)acetamidopenicillanic acid6$eta$-[trans-3-(p-chlorophenyl)-5-oxo-pyrrolidin-2-yl]acetamidopenicillanic acid6$eta$-[trans-3-(p-bromophenyl)-5-oxo-pyrrolidin-2-yl]acetamidopenicillanic acid7$eta$-(trans-3-phenyl-5-oxo-pyrrolidin-2-yl)acetamidopenicillanic acid7$eta$-[trans-3-(p-chlorophenyl)-5-oxo-pyrrolidin-2-yl]acetamidopenicillanic acid7$eta$-[trans-3-(p-bromophenyl)-5-oxo-pyrrolidin-2-yl]acetamidopenicillanic acidantibacterial activity
