The mechanics related with piston-slap induced vibration has been studied in terms of non-dimensionalized dynamic equation of motion, various non-dimensional parameters such as non-dimensional side-thrust force and non-dimensional impact velocity throughout the numerical simulation. Experimental verification on the suggested prediction method has been also performed by using single cylinder engine which was carefully designed and manufactured to wisely control the engine parameters, especially clearance and the mass of piston. The predicted and experimentally observed vibration signature confirm that the proposed method is practically useful.